Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial (Active) — (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Purity >95%.
| Product SKU | BCACP-000454 |
| Product Description | Recombinant Human T-cell surface glycoprotein CD4 (CD4) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 26-396aa. [Accession | P01730]. |
| Uniprot No. | P01730 |
| Gene Names | CD4 |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Expression System | Mammalian cell |
| Expression Region | 26-396aa |
| Species | Homo sapiens (Human) |
| Tag Info | C-terminal 10xHis-tagged |
| Molecular weight | 42.7 kDa |
| Activity | Measured by its binding ability in a functional ELISA.Immobilized Human MICB at 2 μg/mL can bind Anti-MICA/B recombinant antibody. The EC50 is 0.9180-1.062 ng/mL. |
| Buffer | Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0 |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Alternative Names | T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4 |
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Down-regulated by HIV-1 Vpu.
Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial (Active) — (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Purity >95%. Suitable for ELISA and Western Blot applications. Explore more CD proteins →
SDS-PAGE: Single band at expected molecular weight confirming purity.
ELISA: Suitable as coating antigen or detection standard.
Western Blot: Compatible with standard Western Blot protocols.
Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.
Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.
Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.
Shelf Life: 12 months from date of receipt when stored as recommended.
Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:12089508, PubMed:16331979, PubMed:2214026, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607)
Cell membrane (Single-pass type I membrane protein)
Immunodeficiency 79 (IMD79) : An autosomal recessive disorder characterized by childhood onset of recurrent and recalcitrant skin warts due to uncontrolled viral infection with human papillomavirus (HPV). Some patients may also have recurrent respiratory infections. Laboratory studies show a complete absence of CD4+ T cells. [The disease is caused by variants affecting the gene represented in this entry]
Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells
(Microbial infection) Interacts with Human Herpes virus 7 surface proteins
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Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.
Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.
Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.
