Recombinant Human C-type lectin domain family 7 member A (CLEC7A), partial (Active)

Function

Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity)

Subcellular Location

Cytoplasm

Disease Association

Candidiasis, familial, 4 (CANDF4) : A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta

Subunit

Interacts with RANBP9

• Sobanov Y. et al. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. — Eur. J. Immunol. (2001)
• Yokota K. et al. Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1. — Gene (2001)
• Hermanz-Falcon P. et al. Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells. — Immunogenetics (2001)
• Willment J.A. et al. Characterization of the human beta-glucan receptor and its alternatively spliced isoforms. — J. Biol. Chem. (2001)
• Gruenebach F. et al. Molecular and functional characterization of human Dectin-1. — Exp. Hematol. (2002)
• Clark H.F. et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. — Genome Res. (2003)
• Ota T. et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. — Nat. Genet. (2004)
• Scherer S.E. et al. The finished DNA sequence of human chromosome 12. — Nature (2006)