Recombinant Human C-C motif chemokine 8 protein (CCL8), Homo sapiens (Human), E.Coli, Tag-Free, 8.9 kDa, purity >>96% as determined by SDS-PAGE.
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Recombinant Human C-C motif chemokine 8 protein (CCL8)

Recombinant Human C-C motif chemokine 8 protein (CCL8) — Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. Purity >96%.

SKU: BCACP-000765 Categories: ,
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Product SKUBCACP-000765
Product DescriptionRecombinant Human C-C motif chemokine 8 protein (CCL8) protein is expressed from E.Coli with Tag-Free. It contains 24-99aa. [Accession | P80075].
Uniprot No.P80075
Gene NamesCCL8
Purity>96% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region24-99aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight8.9 kDa
ActivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 5.0-20 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCcl8; CCL8_HUMAN; HC14; MCP-2; MCP-2(6-76); Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; SCYA10; SCYA8; Small-inducible cytokine A8

Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate

Product Specifications

Recombinant Human C-C motif chemokine 8 protein (CCL8) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 24-99aa, with Tag-Free tag, molecular weight 8.9 kDa, purity >96% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8

Subcellular Location

Secreted

Tissue Specificity

Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate

Subunit

Monomer or homodimer; in equilibrium

Gene: CCL8  |  Organism: Homo sapiens  |  Synonyms: HC14; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; Small-inducible cytokine A8
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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