Function
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
Biological Context
Subcellular Location: Secreted
Tissue Specificity: Liver and intestine
Disease Association: Hyperlipoproteinemia 1B (HLPP1B) : Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Apolipoprotein C-II (APOC2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 23-101aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 24.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
