Recombinant Human Leucine-rich repeat LGI family member 4 (LGI4), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 61.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Leucine-rich repeat LGI family member 4 (LGI4)

Recombinant Human Leucine-rich repeat LGI family member 4 (LGI4) — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-001063 Category:
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Product Specifications

Product SkuBCRECP-001063
Product DescriptionRecombinant Human Leucine-rich repeat LGI family member 4 (LGI4) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 20-537aa. [Accession | Q8N135].
Uniprot No.Q8N135
Gene NamesLGI4
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region20-537aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight61.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Widely expressed, with highest expression in brain
Disease Association: Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect (AMC1) : A form of arthrogryposis multiplex congenita, a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. AMC1 is an autosomal recessive severe form with onset in utero. Most affected individuals die in utero. Those who survive have generalized contractures and hypotonia. The disorder is caused by a neurogenic defect and poor or absent myelin formation around peripheral nerves rather than by a muscular defect. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Leucine-rich repeat LGI family member 4 (LGI4) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 20-537aa, with N-terminal 6xHis-tagged tag, molecular weight 61.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity)

Subcellular Location

Secreted

Disease Association

Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect (AMC1) : A form of arthrogryposis multiplex congenita, a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. AMC1 is an autosomal recessive severe form with onset in utero. Most affected individuals die in utero. Those who survive have generalized contractures and hypotonia. The disorder is caused by a neurogenic defect and poor or absent myelin formation around peripheral nerves rather than by a muscular defect. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed, with highest expression in brain

Subunit

Can bind to ADAM11, ADAM22 and ADAM23

Gene: LGI4  |  Organism: Homo sapiens  |  Synonyms: LGI1-like protein 3; Leucine-rich glioma-inactivated protein 4
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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