Recombinant Human Transformer-2 protein homolog beta (TRA2B), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 26.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Transformer-2 protein homolog beta (TRA2B), partial

Recombinant Human Transformer-2 protein homolog beta (TRA2B), partial — Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Purity >85%.

SKU: BCRECP-001833 Category:
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Product Specifications

Product SkuBCRECP-001833
Product DescriptionRecombinant Human Transformer-2 protein homolog beta (TRA2B) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 111-201aa. [Accession | P62995].
Uniprot No.P62995
Gene NamesTRA2B
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region111-201aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight26.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver
Disease Association: Ramond-Elliott neurodevelopmental syndrome (RAMELN) : An autosomal dominant disorder manifesting in infancy or the first years of life, and characterized by global developmental delay, hypotonia, delayed walking or inability to walk, intellectual disability, poor or absent speech, and behavioral problems. Affected individuals frequently develop infantile spasms that may be severe and refractory. Additional variable features include poor overall growth, dysmorphic facial features, feeding difficulties, and brain anomalies. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Transformer-2 protein homolog beta (TRA2B), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 111-201aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 26.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA

Subcellular Location

Nucleus

Disease Association

Ramond-Elliott neurodevelopmental syndrome (RAMELN) : An autosomal dominant disorder manifesting in infancy or the first years of life, and characterized by global developmental delay, hypotonia, delayed walking or inability to walk, intellectual disability, poor or absent speech, and behavioral problems. Affected individuals frequently develop infantile spasms that may be severe and refractory. Additional variable features include poor overall growth, dysmorphic facial features, feeding difficulties, and brain anomalies. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver

Subunit

Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1 (PubMed:10339552). Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A (PubMed:10749975, PubMed:12165565, PubMed:14729963, PubMed:14765198, PubMed:15169763, PubMed:19282290). Interacts with SAFB/SAFB1 (By similarity). Interacts with ILDR1 (via C-terminus) and ILDR2 (By similarity)

Gene: TRA2B  |  Organism: Homo sapiens  |  Synonyms: Splicing factor, arginine/serine-rich 10; Transformer-2 protein homolog B
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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