Recombinant Dog Brain-derived neurotrophic factor (BDNF), Canis lupus familiaris (Dog) (Canis familiaris), E.coli, N-terminal 6xHis-tagged, 19.6kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Dog Brain-derived neurotrophic factor (BDNF)

Recombinant Dog Brain-derived neurotrophic factor (BDNF) — Important signaling molecule that activates signaling cascades downstream of NTRK2. Purity >90%.

SKU: BCRECP-002189 Categories: ,
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Product Specifications

Product SkuBCRECP-002189
Product DescriptionRecombinant Dog Brain-derived neurotrophic factor (BDNF) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 129-247aa. [Accession | Q7YRB4].
Uniprot No.Q7YRB4
Gene NamesBDNF
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region129-247aa
SpeciesCanis lupus familiaris (Dog) (Canis familiaris)
Tag InfoN-terminal 6xHis-tagged
Molecular weight19.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Dog Brain-derived neurotrophic factor (BDNF) is a recombinant protein from Canis lupus familiaris (Dog) (Canis familiaris), expressed in E.coli, covering amino acids 129-247aa, with N-terminal 6xHis-tagged tag, molecular weight 19.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity)

Subcellular Location

Secreted

Subunit

Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity)

Gene: BDNF  |  Organism: Canis lupus familiaris  |  Synonyms: Brain-derived neurotrophic factor

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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