Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active), Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 41.1 kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active)

Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active) — recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system. Purity >85%.

SKU: BCACP-000043 Categories: ,
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Product SKUBCACP-000043
Product DescriptionRecombinant Human Atypical chemokine receptor 1 (ACKR1) protein is expressed from in vitro E.coli expression system with N-terminal 10xHis-tagged. It contains 1-336aa. [Accession | Q16570].
Uniprot No.Q16570
Gene NamesACKR1
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-336aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight41.1 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized ACKR1 at 1 μg/ml can bind human CCL2, the EC50 of human CCL2 protein is 48.64-60.24 μg/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesACKR1; DARC; FY; GPD; Atypical chemokine receptor 1; Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD antigen CD234

Function

(Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi.

Biological Context

Subcellular Location: Early endosome; Recycling endosome; Membrane (Multi-pass membrane protein)
Tissue Specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium

Product Specifications

Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active) is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-336aa, with N-terminal 10xHis-tagged tag, molecular weight 41.1 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized ACKR1 at 1 μg/ml can bind human CCL2, the EC50 of human CCL2 protein is 48.64-60.24 μg/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi

Subcellular Location

Early endosome; Recycling endosome; Membrane (Multi-pass membrane protein)

Tissue Specificity

Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium

Subunit

(Microbial infection) Interacts (via N-terminal extracellular domain) with Plasmodium knowlesi Duffy receptor alpha form (DBPalpha) (via region II)

Gene: ACKR1  |  Organism: Homo sapiens  |  Synonyms: Duffy antigen receptor for chemokines; Duffy antigen/chemokine receptor; Duffy blood group antigen; Fy glycoprotein; Glycoprotein D; Plasmodium vivax receptor
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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