Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active), Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 41.1 kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active)

Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active) — recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system. Purity >85%.

SKU: BCACP-000043 Categories: ,
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Product SKUBCACP-000043
Product DescriptionRecombinant Human Atypical chemokine receptor 1 (ACKR1) protein is expressed from in vitro E.coli expression system with N-terminal 10xHis-tagged. It contains 1-336aa. [Accession | Q16570].
Uniprot No.Q16570
Gene NamesACKR1
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-336aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight41.1 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized ACKR1 at 1 μg/ml can bind human CCL2, the EC50 of human CCL2 protein is 48.64-60.24 μg/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesACKR1; DARC; FY; GPD; Atypical chemokine receptor 1; Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD antigen CD234

Function

(Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi.

Biological Context

Subcellular Location: Early endosome; Recycling endosome; Membrane (Multi-pass membrane protein)
Tissue Specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium

Product Specifications

Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active) is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-336aa, with N-terminal 10xHis-tagged tag, molecular weight 41.1 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

(Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi

Subcellular Location

Early endosome; Recycling endosome; Membrane (Multi-pass membrane protein)

Tissue Specificity

Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium

Subunit

(Microbial infection) Interacts (via N-terminal extracellular domain) with Plasmodium knowlesi Duffy receptor alpha form (DBPalpha) (via region II)

Gene: ACKR1  |  Organism: Homo sapiens  |  Synonyms: Duffy antigen receptor for chemokines; Duffy antigen/chemokine receptor; Duffy blood group antigen; Fy glycoprotein; Glycoprotein D; Plasmodium vivax receptor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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