Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),Partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-mFc-tagged, 43.1 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),Partial (Active)

Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),Partial (Active) — Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, tra…

SKU: BCACP-000406 Categories: ,
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Product SKUBCACP-000406
Product DescriptionRecombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B), Partial protein is expressed from Mammalian cell with C-terminal 10xHis-mFc-tagged. It contains 29-159aa. [Accession | P40259].
Uniprot No.P40259
Gene NamesCD79B
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region29-159aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-mFc-tagged
Molecular weight43.1 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human NCR3LG1 at 2 μg/mL can bind Anti-NCR3LG1 recombinant antibody. The EC50 is 10.90-12.22 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesB-cell-specific glycoprotein B29;Ig-beta;Immunoglobulin-associated B29 protein;CD antigen CD79b

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Product Specifications

Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),Partial (Active) — Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, tra… Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human NCR3LG1 at 2 μg/mL can bind Anti-NCR3LG1 recombinant antibody. The EC50 is 10.90-12.22 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

Agammaglobulinemia 6, autosomal recessive (AGM6) : A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

B-cells

Subunit

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains (PubMed:35981043). Interacts with LYN (By similarity)

Gene: CD79B  |  Organism: Homo sapiens  |  Synonyms: B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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