Recombinant Human Cadherin-3 (CDH3), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 70.8 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Cadherin-3 (CDH3), partial (Active)

Recombinant Human Cadherin-3 (CDH3), partial (Active) — Cadherins are calcium-dependent cell adhesion proteins. Purity >95%.

SKU: BCACP-000659 Category:
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Product SKUBCACP-000659
Product DescriptionRecombinant Human Cadherin-3 (CDH3) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 25-654aa. [Accession | P22223].
Uniprot No.P22223
Gene NamesCDH3
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region25-654aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight70.8 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human LAIR1 at 2 μg/mL can bind Anti-LAIR1 recombinant antibody . The EC50 is 0.9493-1.090 ng/mL.;LAIR1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human LAIR1 with an affinity constant of 0.329 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCadherin-3; Placental cadherin; P-cadherin

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines
Disease Association: Hypotrichosis congenital with juvenile macular dystrophy (HJMD) : A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life. [The disease is caused by variants affecting the gene represented in this entry] | Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS) : A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Cadherin-3 (CDH3), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 25-654aa, with C-terminal 10xHis-tagged tag, molecular weight 70.8 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

Hypotrichosis congenital with juvenile macular dystrophy (HJMD) : A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life. [The disease is caused by variants affecting the gene represented in this entry] | Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS) : A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in some normal epithelial tissues and in some carcinoma cell lines

Subunit

Interacts with CDCP1 and CTNNB1

Gene: CDH3  |  Organism: Homo sapiens  |  Synonyms: Placental cadherin
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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