Recombinant Human G-protein coupled receptor 62 (GPR62) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 39.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human G-protein coupled receptor 62 (GPR62) Protein

Recombinant Human G-protein coupled receptor 62 (GPR62) Protein — Orphan G protein-coupled receptor. Purity >85%.

SKU: BCRECP-00213TM Category:
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Product Specifications

Uniprot No.Q9BZJ7
Gene NamesGPR62
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-368aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight39.1kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Orphan G protein-coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Endosome membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus

Product Specifications

Recombinant Human G-protein coupled receptor 62 (GPR62) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-368aa, with N-terminal 10xHis-tagged tag, molecular weight 39.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Orphan G protein-coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Endosome membrane (Multi-pass membrane protein)

Tissue Specificity

Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus

Subunit

Homodimers (By similarity). Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR62 in the endosomal compartment (PubMed:28827538)

Gene: GPR62  |  Organism: Homo sapiens  |  Synonyms: G protein-coupled receptor GPCR8; G protein-coupled receptor KPG_005

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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