Recombinant Human Growth hormone receptor (GHR), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 44.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Growth hormone receptor (GHR), partial

Recombinant Human Growth hormone receptor (GHR), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000741 Category:
Online Inquiry →

Product Specifications

Product SkuBCRECP-000741
Product DescriptionRecombinant Human Growth hormone receptor (GHR) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 19-264aa. [Accession | P10912].
Uniprot No.P10912
Gene NamesGHR
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region19-264aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight44.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Predominantly expressed in kidney, bladder, adrenal gland and brain stem. Highly expressed in placental villi
Disease Association: Laron syndrome (LARS) : A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone insensitivity, partial (GHIP) : A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Growth hormone receptor (GHR), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 19-264aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 44.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling

Subcellular Location

Secreted

Disease Association

Laron syndrome (LARS) : A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone insensitivity, partial (GHIP) : A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in kidney, bladder, adrenal gland and brain stem (PubMed:1569971). Highly expressed in placental villi (PubMed:1569971, PubMed:8360189)

Subunit

On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain

Gene: GHR  |  Organism: Homo sapiens  |  Synonyms: Somatotropin receptor
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top