Recombinant Human Growth hormone receptor (GHR), partial,Biotinylated (Active), Homo sapiens (Human), Mammalian cell, C-terminal mFc-Avi-tagged, 56.6 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Growth hormone receptor (GHR), partial,Biotinylated (Active)

Recombinant Human Growth hormone receptor (GHR), partial,Biotinylated (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCACP-000108 Categories: , ,
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Product SKUBCACP-000108
Product DescriptionRecombinant Human Growth hormone receptor (GHR), Biotinylated protein is expressed from Mammalian cell with C-terminal mFc-Avi-tagged. It contains 27-264aa. [Accession | P10912].
Uniprot No.P10912
Gene NamesGHR
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-264aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal mFc-Avi-tagged
Molecular weight56.6 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L, the EC50 is 14.96-20.25 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(GH-binding protein)(GHBP)(Serum-binding protein)

Function

Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Predominantly expressed in kidney, bladder, adrenal gland and brain stem. Highly expressed in placental villi
Disease Association: Laron syndrome (LARS) : A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone insensitivity, partial (GHIP) : A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Growth hormone receptor (GHR), partial,Biotinylated (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-264aa, with C-terminal mFc-Avi-tagged tag, molecular weight 56.6 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L, the EC50 is 14.96-20.25 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling

Subcellular Location

Secreted

Disease Association

Laron syndrome (LARS) : A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone insensitivity, partial (GHIP) : A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in kidney, bladder, adrenal gland and brain stem (PubMed:1569971). Highly expressed in placental villi (PubMed:1569971, PubMed:8360189)

Subunit

On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain

Gene: GHR  |  Organism: Homo sapiens  |  Synonyms: Somatotropin receptor
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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