Recombinant Human Hemojuvelin (HJV) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 40.6 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Hemojuvelin (HJV) (Active)

Recombinant Human Hemojuvelin (HJV) (Active) — Acts as a bone morphogenetic protein (BMP) coreceptor. Purity >95%.

SKU: BCACP-000630 Category:
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Product SKUBCACP-000630
Product DescriptionRecombinant Human Hemojuvelin (HJV) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 36-400aa. [Accession | Q6ZVN8].
Uniprot No.Q6ZVN8
Gene NamesHJV
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region36-400aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight40.6 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human ENTPD1 at 2 μg/mL can bind Anti-ENTPD1 recombinant antibody . The EC50 is 5.294-6.760 ng/mL.;NPR1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human ENTPD1 with an affinity constant of 1.07 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesHemojuvelin; Hemochromatosis type 2 protein; Hemojuvelin BMP coreceptor; RGM domain family member C

Function

Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor)
Tissue Specificity: Adult and fetal liver, heart, and skeletal muscle
Disease Association: Hemochromatosis 2A (HFE2A) : A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hemojuvelin (HJV) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 36-400aa, with C-terminal 10xHis-tagged tag, molecular weight 40.6 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ENTPD1 at 2 μg/mL can bind Anti-ENTPD1 recombinant antibody . The EC50 is 5.294-6.760 ng/mL.;NPR1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human ENTPD1 with an affinity constant of 1.07 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor)

Disease Association

Hemochromatosis 2A (HFE2A) : A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Adult and fetal liver, heart, and skeletal muscle

Subunit

Interacts with BMP2 and BMP4 (By similarity). Interacts with BMP6 (By similarity). Interacts with BMPR1B (PubMed:16604073). Interacts with TMPRSS6 (PubMed:18976966, PubMed:19357398)

Gene: HJV  |  Organism: Homo sapiens  |  Synonyms: Hemochromatosis type 2 protein; Hemojuvelin BMP coreceptor; RGM domain family member C
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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