Recombinant Human Hemojuvelin (HJV) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 40.6 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Hemojuvelin (HJV) (Active)

Recombinant Human Hemojuvelin (HJV) (Active) — Acts as a bone morphogenetic protein (BMP) coreceptor. Purity >95%.

SKU: BCACP-000630 Category:
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Product SKUBCACP-000630
Product DescriptionRecombinant Human Hemojuvelin (HJV) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 36-400aa. [Accession | Q6ZVN8].
Uniprot No.Q6ZVN8
Gene NamesHJV
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region36-400aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight40.6 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human ENTPD1 at 2 μg/mL can bind Anti-ENTPD1 recombinant antibody . The EC50 is 5.294-6.760 ng/mL.;NPR1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human ENTPD1 with an affinity constant of 1.07 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesHemojuvelin; Hemochromatosis type 2 protein; Hemojuvelin BMP coreceptor; RGM domain family member C

Function

Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor)
Tissue Specificity: Adult and fetal liver, heart, and skeletal muscle
Disease Association: Hemochromatosis 2A (HFE2A) : A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hemojuvelin (HJV) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 36-400aa, with C-terminal 10xHis-tagged tag, molecular weight 40.6 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor)

Disease Association

Hemochromatosis 2A (HFE2A) : A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Adult and fetal liver, heart, and skeletal muscle

Subunit

Interacts with BMP2 and BMP4 (By similarity). Interacts with BMP6 (By similarity). Interacts with BMPR1B (PubMed:16604073). Interacts with TMPRSS6 (PubMed:18976966, PubMed:19357398)

Gene: HJV  |  Organism: Homo sapiens  |  Synonyms: Hemochromatosis type 2 protein; Hemojuvelin BMP coreceptor; RGM domain family member C
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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