Recombinant Human Interleukin-21 (IL21) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 44.4 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Interleukin-21 (IL21) (Active)

Recombinant Human Interleukin-21 (IL21) (Active) — Cytokine with immunoregulatory activity. Purity >90%.

SKU: BCACP-000635 Categories: ,
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Product SKUBCACP-000635
Product DescriptionRecombinant Human Interleukin-21 (IL21) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 23-155aa. [Accession | Q9HBE4].
Uniprot No.Q9HBE4
Gene NamesIL21
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region23-155aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight44.4 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis LGR5 at 2 μg/mL can bind anti-LGR5 recombinant antibody.The EC50 is 15.10-19.23 ng/mL.;LGR5 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Macaca fascicularis LGR5 with an affinity constant of 0.362 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-21; IL-21; Za11

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells.

Product Specifications

Recombinant Human Interleukin-21 (IL21) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 23-155aa, with C-terminal hFc1-tagged tag, molecular weight 44.4 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis LGR5 at 2 μg/mL can bind anti-LGR5 recombinant antibody.The EC50 is 15.10-19.23 ng/mL.;LGR5 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Macaca fascicularis LGR5 with an affinity constant of 0.362 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity)

Gene: IL21  |  Organism: Homo sapiens

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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