Recombinant Mouse Interleukin-21 (Il21), partial (Active), Mus musculus (Mouse), Mammalian cell, C-terminal hFc1-tagged, 43.2 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Mouse Interleukin-21 (Il21), partial (Active)

Recombinant Mouse Interleukin-21 (Il21), partial (Active) — Cytokine with immunoregulatory activity. Purity >90%.

SKU: BCACP-000649 Categories: ,
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Product SKUBCACP-000649
Product DescriptionRecombinant Mouse Interleukin-21 (Il21) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 25-146aa. [Accession | Q9ES17].
Uniprot No.Q9ES17
Gene NamesIl21
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region25-146aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal hFc1-tagged
Molecular weight43.2 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CLEC5A at 2 μg/mL can bind Anti-CLEC5A recombinant antibody . The EC50 is 0.3246-0.4731 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CLEC5A at 2 μg/mL can bind Anti-CLEC5A recombinant antibody . The EC50 is 1.553-1.763 ng/mL.;CLEC5A Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human CLEC5A with an affinity constant of 0.444 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-21; IL-21

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in CD4(+) T cells

Product Specifications

Recombinant Mouse Interleukin-21 (Il21), partial (Active) is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 25-146aa, with C-terminal hFc1-tagged tag, molecular weight 43.2 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLEC5A at 2 μg/mL can bind Anti-CLEC5A recombinant antibody . The EC50 is 0.3246-0.4731 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CLEC5A at 2 μg/mL can bind Anti-CLEC5A recombinant antibody . The EC50 is 1.553-1.763 ng/mL.;CLEC5A Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human CLEC5A with an affinity constant of 0.444 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (PubMed:15100251). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 (PubMed:11970879). May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (PubMed:12893770)

Subcellular Location

Secreted

Tissue Specificity

Expressed in CD4(+) T cells

Gene: Il21  |  Organism: Mus musculus
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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