Recombinant Human Malate dehydrogenase, cytoplasmic (MDH1) (Active), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 37.5 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Malate dehydrogenase, cytoplasmic (MDH1) (Active)

Recombinant Human Malate dehydrogenase, cytoplasmic (MDH1) (Active) — Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Purity >95%.

SKU: BCACP-001099 Categories: ,
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Product SKUBCACP-001099
Product DescriptionRecombinant Human Malate dehydrogenase, cytoplasmic (MDH1) protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 2-334aa. [Accession | P40925].
Uniprot No.P40925
Gene NamesMDH1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-334aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight37.5 kDa
ActivityThe ED50 as determined by its ability to bind Human EphA2 in functional ELISA is less than 10 ug/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Namescytoplasmic; Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase; Malate dehydrogenase 1, NAD (soluble); Malate dehydrogenase; Malate dehydrogenase cytoplasmic; MDH s; mdh1; MDHA; MDHC_HUMAN; MDHs; MGC:1375; MOR2; Soluble malate dehydrogenase

Function

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation.

Product Specifications

Recombinant Human Malate dehydrogenase, cytoplasmic (MDH1) (Active) — Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Purity >95%. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined by its ability to bind Human EphA2 in functional ELISA is less than 10 ug/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073)

Subcellular Location

Cytoplasm, cytosol

Disease Association

Developmental and epileptic encephalopathy 88 (DEE88) : A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE88 is an autosomal recessive severe form characterized by global developmental delay, epilepsy, and progressive microcephaly. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homodimer

Gene: MDH1  |  Organism: Homo sapiens  |  Synonyms: Aromatic alpha-keto acid reductase; Cytosolic malate dehydrogenase

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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