Recombinant Human Malate dehydrogenase, Cytoplasmic (MDH1), partial, Homo sapiens (Human), E.coli, N-terminal GST-tagged, 63.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Malate dehydrogenase, Cytoplasmic (MDH1), partial

Recombinant Human Malate dehydrogenase, Cytoplasmic (MDH1), partial — Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Purity >90%.

SKU: BCRECP-001142 Categories: ,
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Product Specifications

Product SkuBCRECP-001142
Product DescriptionRecombinant Human Malate dehydrogenase, Cytoplasmic (MDH1) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 2-333aa. [Accession | P40925].
Uniprot No.P40925
Gene NamesMDHA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-333aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight63.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).

Biological Context

Subcellular Location: Cytoplasm, cytosol
Disease Association: Developmental and epileptic encephalopathy 88 (DEE88) : A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE88 is an autosomal recessive severe form characterized by global developmental delay, epilepsy, and progressive microcephaly. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Malate dehydrogenase, Cytoplasmic (MDH1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-333aa, with N-terminal GST-tagged tag, molecular weight 63.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073)

Subcellular Location

Cytoplasm, cytosol

Disease Association

Developmental and epileptic encephalopathy 88 (DEE88) : A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE88 is an autosomal recessive severe form characterized by global developmental delay, epilepsy, and progressive microcephaly. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homodimer

Gene: MDH1  |  Organism: Homo sapiens  |  Synonyms: Aromatic alpha-keto acid reductase; Cytosolic malate dehydrogenase

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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