Function
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription.
Biological Context
Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Ubiquitous
Disease Association: Immunodeficiency 68 (IMD68) : An autosomal recessive primary immunodeficiency characterized by life-threatening, often recurrent, pyogenic bacterial infections, including invasive pneumococcal disease, beginning in infancy or early childhood. [The disease is caused by variants affecting the gene represented in this entry] | Macroglobulinemia, Waldenstrom, 1 (WM1) : A malignant B-cell neoplasm characterized by lymphoplasmacytic infiltration of the bone marrow and hypersecretion of monoclonal immunoglobulin M (IgM) protein. Clinical features are variable and include anemia, thrombocytopenia, hepatosplenomegaly, and lymphadenopathy. Many patients have asymptomatic or indolent disease. [The disease is caused by variants affecting the gene represented in this entry] | [Defects in MYD88 are frequently found in many hematological malignancies, such as activated B-cell type diffuse large B-cell lymphoma (ABC-DLBCL), cutaneous diffuse large B cell lymphoma (CBCL) and primary central nervous system lymphoma (PCNSL)]
Product Specifications
Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-296aa, with N-terminal 6xHis-tagged tag, molecular weight 37.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
