Recombinant Human Neuropilin-1 (NRP1) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 98.8 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Neuropilin-1 (NRP1) (Active)

Recombinant Human Neuropilin-1 (NRP1) (Active) — Binds VEGF-165 and may inhibit its binding to cells. Purity >95%.

SKU: BCACP-000129 Category:
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Product SKUBCACP-000129
Product DescriptionRecombinant Human Neuropilin-1 (NRP1) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 22-644aa. [Accession | O14786].
Uniprot No.O14786
Gene NamesNRP1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region22-644aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight98.8 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Mouse Monoclonal Antibody, the EC50 of N Mouse Monoclonal Antibody is 5.660-6.932 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Recombinant Antibody, the EC50 of N Recombinant Antibody is 29.34-40.67 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Vascular endothelial cell growth factor 165 receptor)(CD304)

Function

Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules

Product Specifications

Recombinant Human Neuropilin-1 (NRP1) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 22-644aa, with C-terminal hFc1-tagged tag, molecular weight 98.8 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity

Subcellular Location

Secreted

Tissue Specificity

The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules

Subunit

(Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 spike protein S1 (via the CendR motif RRAR)

Gene: NRP1  |  Organism: Homo sapiens  |  Synonyms: Vascular endothelial cell growth factor 165 receptor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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