Recombinant Human Neuropilin-1 (NRP1) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 98.8 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Neuropilin-1 (NRP1) (Active)

Recombinant Human Neuropilin-1 (NRP1) (Active) — Binds VEGF-165 and may inhibit its binding to cells. Purity >95%.

SKU: BCACP-000129 Category:
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Product SKUBCACP-000129
Product DescriptionRecombinant Human Neuropilin-1 (NRP1) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 22-644aa. [Accession | O14786].
Uniprot No.O14786
Gene NamesNRP1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region22-644aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight98.8 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Mouse Monoclonal Antibody, the EC50 of N Mouse Monoclonal Antibody is 5.660-6.932 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Recombinant Antibody, the EC50 of N Recombinant Antibody is 29.34-40.67 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Vascular endothelial cell growth factor 165 receptor)(CD304)

Function

Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules

Product Specifications

Recombinant Human Neuropilin-1 (NRP1) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 22-644aa, with C-terminal hFc1-tagged tag, molecular weight 98.8 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Mouse Monoclonal Antibody, the EC50 of N Mouse Monoclonal Antibody is 5.660-6.932 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized N ) at 2 μg/ml can bind N Recombinant Antibody, the EC50 of N Recombinant Antibody is 29.34-40.67 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity

Subcellular Location

Secreted

Tissue Specificity

The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules

Subunit

(Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 spike protein S1 (via the CendR motif RRAR)

Gene: NRP1  |  Organism: Homo sapiens  |  Synonyms: Vascular endothelial cell growth factor 165 receptor
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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