Recombinant Human Noggin (NOG) (Active), Homo sapiens (Human), Mammalian cell, Tag free, 23.0 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Noggin (NOG) (Active)

Recombinant Human Noggin (NOG) (Active) — Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Purity >95%.

SKU: BCACP-001151 Category:
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Product SKUBCACP-001151
Product DescriptionRecombinant Human Noggin (NOG) protein is expressed from Mammalian cell with Tag free. It contains 28-232aa. [Accession | Q13253].
Uniprot No.Q13253
Gene NamesNoggin
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region28-232aa
SpeciesHomo sapiens (Human)
Tag InfoTag free
Molecular weight23.0 kDa
ActivityMeasured in a cell inhibition assay using TF-1 cells at IL4 presence. TheED50 for this effect is ≤0.3ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesNoggin; NOG

Function

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6.

Product Specifications

Recombinant Human Noggin (NOG) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 28-232aa, with Tag free tag, molecular weight 23.0 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured in a cell inhibition assay using TF-1 cells at IL4 presence. TheED50 for this effect is ≤0.3ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732)

Gene: NOG  |  Organism: Homo sapiens

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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