Recombinant Human Plexin-B1 (PLXNB1), partial (Active), Homo sapiens (Human), Mammalian cell, N-terminal mFc-tagged, 83.2 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Plexin-B1 (PLXNB1), partial (Active)

Recombinant Human Plexin-B1 (PLXNB1), partial (Active) — Receptor for SEMA4D. Purity >95%.

SKU: BCACP-000146 Category:
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Product SKUBCACP-000146
Product DescriptionRecombinant Human Plexin-B1 (PLXNB1) protein is expressed from Mammalian cell with N-terminal mFc-tagged. It contains 20-535aa. [Accession | O43157].
Uniprot No.O43157
Gene NamesPLXNB1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region20-535aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal mFc-tagged
Molecular weight83.2 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/mL can bind TNFRSF9（CSB-MP023984HU1）, the EC50 is 2.671-3.702 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Semaphorin receptor SEP)

Function

Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver

Product Specifications

Recombinant Human Plexin-B1 (PLXNB1), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 20-535aa, with N-terminal mFc-tagged tag, molecular weight 83.2 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/mL can bind TNFRSF9（CSB-MP023984HU1）, the EC50 is 2.671-3.702 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496)

Subcellular Location

Secreted

Tissue Specificity

Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver

Subunit

Monomer, and heterodimer with PLXNB2 after proteolytic processing (PubMed:12533544, PubMed:17916560, PubMed:18275816, PubMed:18411422, PubMed:19843518, PubMed:20877282, PubMed:21912513). Binds RAC1 that has been activated by GTP binding (PubMed:11035813, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interaction with SEMA4D promotes binding of cytoplasmic ligands (PubMed:10520995, PubMed:12198496, PubMed:19843518). Interacts with PLXNA1 (By similarity). Interacts with ARHGEF11 and ARHGEF12 (PubMed:12196628). Interacts with ERBB2 (PubMed:15210733). Interacts with MET (PubMed:12198496, PubMed:15184888). Interacts with MST1R (PubMed:15184888). Interacts with RRAS (PubMed:19843518). Interacts with RHOD (PubMed:17916560). Interacts with RND1 (PubMed:12730235, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interacts with NRP1 and NRP2 (PubMed:10520995)

Gene: PLXNB1  |  Organism: Homo sapiens  |  Synonyms: Semaphorin receptor SEP
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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