Recombinant Human Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 139.5 kDa, purity >95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
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Recombinant Human Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial (Active)

Recombinant Human Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial (Active) — Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Purity >95%.

SKU: BCACP-000273 Categories: ,
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Product SKUBCACP-000273
Product DescriptionRecombinant Human Receptor-type tyrosine-protein phosphatase delta (PTPRD) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 21-1265aa. [Accession | P23468].
Uniprot No.P23468
Gene NamesPTPRD
PurityGreater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region21-1265aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight139.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human HSPA5 at 2 μg/mL can bind Anti-HSPA5 recombinant antibody . The EC50 is 3.021-3.531 ng/mL.;HSPA5 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human HSPA5 with an affinity constant of 16.4 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesReceptor-type tyrosine-protein phosphatase delta; EC:3.1.3.48; Protein-tyrosine phosphatase delta; R-PTP-delta; PTPRD

Function

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Human Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 21-1265aa, with C-terminal 10xHis-tagged tag, molecular weight 139.5 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human HSPA5 at 2 μg/mL can bind Anti-HSPA5 recombinant antibody . The EC50 is 3.021-3.531 ng/mL.;HSPA5 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human HSPA5 with an affinity constant of 16.4 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2

Subcellular Location

Membrane (Single-pass type I membrane protein)

Subunit

Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:9624153). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats). Interacts with SLITRK2; induces presynaptic differentiation. Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity)

Gene: PTPRD  |  Organism: Homo sapiens
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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