Recombinant Human Sterol regulatory element-binding protein 1 (SREBF1), partial Protein, Homo sapiens(Human), in vitro E.coli expression system, N-terminal 6xHis-tagged, 54.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Sterol regulatory element-binding protein 1 (SREBF1), partial Protein

Recombinant Human Sterol regulatory element-binding protein 1 (SREBF1), partial Protein — recombinant protein from Homo sapiens(Human), expressed in in vitro E.coli expression system. Purity >90%.

SKU: BCRECP-00613TM Category:
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Product Specifications

Uniprot No.P36956
Gene NamesSREBF1
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-490aa
SpeciesHomo sapiens(Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight54.5kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Predominantly expressed in liver and adipose tissues. Also expressed in kidney, brain, white fat, and muscle
Disease Association: IFAP syndrome 2 (IFAP2) : An autosomal dominant form of IFAP syndrome, a disease characterized by a peculiar triad of follicular ichthyosis, total or subtotal atrichia, and photophobia of varying degree. IFAP2 patients manifest ichthyosis follicularis or follicular hyperkeratosis, hyperkeratotic plaques, sparse to no body hair, and photophobia with punctate corneal epithelial defects, corneal pannus, and complicated cataract. Ultrastructural hair analysis shows trichorrhexis nodosa. [The disease is caused by variants affecting the gene represented in this entry] | Mucoepithelial dysplasia, hereditary (HMD) : An autosomal dominant genodermatosis mainly characterized by chronic mucosal lesions associated with keratitis, non-scarring alopecia, keratosis pilaris and perineal intertrigo. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Sterol regulatory element-binding protein 1 (SREBF1), partial Protein is a recombinant protein from Homo sapiens(Human), expressed in in vitro E.coli expression system, covering amino acids 1-490aa, with N-terminal 6xHis-tagged tag, molecular weight 54.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters

Subcellular Location

Nucleus

Disease Association

IFAP syndrome 2 (IFAP2) : An autosomal dominant form of IFAP syndrome, a disease characterized by a peculiar triad of follicular ichthyosis, total or subtotal atrichia, and photophobia of varying degree. IFAP2 patients manifest ichthyosis follicularis or follicular hyperkeratosis, hyperkeratotic plaques, sparse to no body hair, and photophobia with punctate corneal epithelial defects, corneal pannus, and complicated cataract. Ultrastructural hair analysis shows trichorrhexis nodosa. [The disease is caused by variants affecting the gene represented in this entry] | Mucoepithelial dysplasia, hereditary (HMD) : An autosomal dominant genodermatosis mainly characterized by chronic mucosal lesions associated with keratitis, non-scarring alopecia, keratosis pilaris and perineal intertrigo. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in liver and adipose tissues (PubMed:8402897). Also expressed in kidney, brain, white fat, and muscle (PubMed:8402897)

Subunit

Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein (PubMed:8402897). Interacts with CEBPA, the interaction produces a transcriptional synergy (By similarity). Interacts with LMNA (By similarity)

Gene: SREBF1  |  Organism: Homo sapiens  |  Synonyms: Class D basic helix-loop-helix protein 1; Sterol regulatory element-binding transcription factor 1
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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