Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial (Active) — (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Purity >95%.
| Product SKU | BCACP-000454 |
| Product Description | Recombinant Human T-cell surface glycoprotein CD4 (CD4) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 26-396aa. [Accession | P01730]. |
| Uniprot No. | P01730 |
| Gene Names | CD4 |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Expression System | Mammalian cell |
| Expression Region | 26-396aa |
| Species | Homo sapiens (Human) |
| Tag Info | C-terminal 10xHis-tagged |
| Molecular weight | 42.7 kDa |
| Activity | Measured by its binding ability in a functional ELISA.Immobilized Human MICB at 2 μg/mL can bind Anti-MICA/B recombinant antibody. The EC50 is 0.9180-1.062 ng/mL. |
| Buffer | Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0 |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Alternative Names | T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4 |
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Down-regulated by HIV-1 Vpu.
Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial (Active) — (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Purity >95%. Suitable for ELISA and Western Blot applications. Explore more CD proteins →
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human MICB at 2 μg/mL can bind Anti-MICA/B recombinant antibody. The EC50 is 0.9180-1.062 ng/mL.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:12089508, PubMed:16331979, PubMed:2214026, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607)
Cell membrane (Single-pass type I membrane protein)
Immunodeficiency 79 (IMD79) : An autosomal recessive disorder characterized by childhood onset of recurrent and recalcitrant skin warts due to uncontrolled viral infection with human papillomavirus (HPV). Some patients may also have recurrent respiratory infections. Laboratory studies show a complete absence of CD4+ T cells. [The disease is caused by variants affecting the gene represented in this entry]
Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells
(Microbial infection) Interacts with Human Herpes virus 7 surface proteins
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.
Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.
Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.
