Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
Biological Context
Subcellular Location: Mitochondrion; Cytoplasm; Early endosome
Disease Association: Spinocerebellar ataxia, autosomal recessive, 32 (SCAR32) : A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR32 is characterized by the onset of gait ataxia in the second or third decades of life. Other classic features include upper limb ataxia, oculomotor signs, dysphagia, and dysarthria. Some patients may have hyper- or hypokinetic movement abnormalities. Brain imaging shows cerebellar atrophy. Atrophy can extend to the brainstem and medullary olives. [The disease is caused by variants affecting the gene represented in this entry] | Corneal dystrophy, punctiform and polychromatic pre-Descemet (PPPCD) : An autosomal dominant corneal dystrophy characterized by the presence of punctiform, multicolored opacities in the posterior stroma, immediately anterior to Descemet membrane. Affected individuals are typically asymptomatic. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 63-256aa, with N-terminal 6xHis-tagged tag, molecular weight 25.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications. Explore more Enzyme proteins →
