Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Biological Context
Subcellular Location: Secreted
Disease Association: Thrombocythemia 1 (THCYT1) : A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. [The disease is caused by variants affecting the gene represented in this entry] | Amegakaryocytic thrombocytopenia, congenital, 2 (CAMT2) : A form of congenital amegakaryocytic thrombocytopenia, a hematologic disorder characterized by severe reduction of megakaryocytes and platelets at birth, and evolving into generalized bone marrow aplasia during childhood. CAMT2 is an autosomal recessive form. Most patients present with thrombocytopenia that progresses to pancytopenia. [The disease is caused by variants affecting the gene represented in this entry] | Thrombocytopenia 9 (THC9) : A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC9 is an autosomal dominant form characterized by low platelet counts in the absence of significant bleeding tendency. Some individuals may have mild mucocutaneous bleeding, whereas others may be asymptomatic. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Thrombopoietin/TPO Protein is a recombinant protein, expressed in HEK293 Cells, covering amino acids 22-353aa, with C-6His tag, molecular weight 90 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
