Recombinant Human Vasopressin V2 receptor (AVPR2) Protein

Function

G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption (PubMed:1534149, PubMed:19440390, PubMed:33664408, PubMed:33742150). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:33664408, PubMed:33742150). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:33664408, PubMed:33742150)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) : Characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. [The disease is caused by variants affecting the gene represented in this entry] | Diabetes insipidus, nephrogenic, 1, X-linked (NDI1) : A disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Kidney

Subunit

Interacts with ARRDC4 (PubMed:23236378). Identified in a complex containing at least ARRDC4, V2R and HGS (PubMed:23236378). Interacts with TMEM147 (PubMed:21056967). Interacts (when phosphorylated) with ARRB2; the interaction is associated with internalization of the receptor and short-term desensitization to the ligand (PubMed:37209686)

• Seibold A. et al. Structure and chromosomal localization of the human antidiuretic hormone receptor gene. — Am. J. Hum. Genet. (1992)
• Birnbaumer M. et al. Molecular cloning of the receptor for human antidiuretic hormone. — Nature (1992)
• Wildin R.S. et al. Heterogeneous AVPR2 gene mutations in congenital nephrogenic diabetes insipidus. — Am. J. Hum. Genet. (1994)
• Fay M.J. et al. Evidence for expression of vasopressin V2 receptor mRNA in human lung. — Peptides (1996)
• North W.G. et al. Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. — Cancer Res. (1998)
• Boselt I. et al. Involvement of the V2 vasopressin receptor in adaptation to limited water supply. — PLoS ONE (2009)
• Warren C.N. et al. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org). (FEB-)
• Mural R.J. et al. PubMed: CI-5GBD0VIIJ7C63 (SEP-)