Recombinant Mouse Apelin receptor (Aplnr)-VLPs Protein

Function

G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway leading to internalization of the receptor (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). APLNR/APJ receptor is also activated by mechanical strech in a G-protein-independent fashion to induce beta-arrestin signaling leading to cardiac hypertrophy (PubMed:22810587). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (PubMed:28663440, PubMed:28854362, PubMed:28890073). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (PubMed:28890073). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure and heart contractility and protection from cardiac hypertrophy and heart failure (PubMed:22810587, PubMed:28371822)