Recombinant Mouse C-C motif chemokine 21c protein (Ccl21c), Mus musculus (Mouse), E.Coli, Tag-Free, 12.1 kDa, purity >>97% as determined by SDS-PAGE.
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Recombinant Mouse C-C motif chemokine 21c protein (Ccl21c)

Recombinant Mouse C-C motif chemokine 21c protein (Ccl21c) — Binds to chemokine receptors CCR7 and CXCR3. Purity >97%.

SKU: BCACP-000808 Categories: ,
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Product SKUBCACP-000808
Product DescriptionRecombinant Mouse C-C motif chemokine 21c protein (Ccl21c) protein is expressed from E.Coli with Tag-Free. It contains 24-133aa. [Accession | P86793].
Uniprot No.P86793
Gene NamesCcl21c
Purity>97% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region24-133aa
SpeciesMus musculus (Mouse)
Tag InfoTag-Free
Molecular weight12.1 kDa
ActivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 5.0-50 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCcl21c; Scya21cC-C motif chemokine 21c; 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21c; Thymus-derived chemotactic agent 4; TCA4

Function

Binds to chemokine receptors CCR7 and CXCR3. Also binds to G protein-coupled receptor GPR174. Inhibits hemopoiesis and stimulates chemotaxis.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart

Product Specifications

Recombinant Mouse C-C motif chemokine 21c protein (Ccl21c) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 24-133aa, with Tag-Free tag, molecular weight 12.1 kDa, purity >97% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Binds to chemokine receptors CCR7 and CXCR3. Also binds to G protein-coupled receptor GPR174 (By similarity). Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs

Subcellular Location

Secreted

Tissue Specificity

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart

Subunit

Monomer (By similarity). Interacts with PDPN; relocalizes PDPN to the basolateral membrane (By similarity). Interacts with TNFAIP6 (via Link domain) (By similarity)

Gene: Ccl21c  |  Organism: Mus musculus  |  Synonyms: 6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21c; Thymus-derived chemotactic agent 4

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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