Recombinant Mouse Cardiotrophin-1 protein (Ctf1), Mus musculus (Mouse), E.Coli, Tag-Free, 21.5 kDa, purity >>95% as determined by SDS­PAGE.

Recombinant Mouse Cardiotrophin-1 protein (Ctf1)

Recombinant Mouse Cardiotrophin-1 protein (Ctf1) — Functions as a cytokine that binds to the LIF receptor complex. Purity >95%.

SKU: BCACP-000876 Category:
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Product SKUBCACP-000876
Product DescriptionRecombinant Mouse Cardiotrophin-1 protein (Ctf1) protein is expressed from E.Coli with Tag-Free. It contains 1-203aa. [Accession | Q60753].
Uniprot No.Q60753
Gene NamesCtf1
Purity>95% as determined by SDS­PAGE.
Expression SystemE.Coli
Expression Region1-203aa
SpeciesMus musculus (Mouse)
Tag InfoTag-Free
Molecular weight21.5 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/m.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCtf1Cardiotrophin-1; CT-1

Function

Functions as a cytokine that binds to the LIF receptor complex. The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell. Functionnally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen

Product Specifications

Recombinant Mouse Cardiotrophin-1 protein (Ctf1) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 1-203aa, with Tag-Free tag, molecular weight 21.5 kDa, purity >95% as determined by SDS­PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/m.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Functions as a cytokine that binds to the LIF receptor complex (PubMed:7738033, PubMed:9030543). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (PubMed:7738033, PubMed:9030543). Functionnally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy (PubMed:7862649, PubMed:8625793, PubMed:9050750). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains (PubMed:9030543). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:9030543). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (PubMed:9030543)

Subcellular Location

Secreted

Tissue Specificity

Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen

Gene: Ctf1  |  Organism: Mus musculus

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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