Recombinant Mouse CD40 ligand (Cd40lg), partial (Active), Mus musculus (Mouse), Mammalian cell, N-terminal mFc1-tagged, 42.1 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Mouse CD40 ligand (Cd40lg), partial (Active)

Recombinant Mouse CD40 ligand (Cd40lg), partial (Active) — recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell. Purity >95%.

SKU: BCACP-000400 Categories: ,
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Product SKUBCACP-000400
Product DescriptionRecombinant Mouse CD40 ligand (Cd40lg) protein is expressed from Mammalian cell with N-terminal mFc1-tagged. It contains 112-260aa. [Accession | P27548].
Uniprot No.P27548
Gene NamesCd40lg
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region112-260aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal mFc1-tagged
Molecular weight42.1 kDa
ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 0.3149 to 1.023 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCD40 ligand;CD40-L; T-cell antigen Gp39TNF-related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD154; Cd40lg; Cd40l, Tnfsf5

Function

Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Specifically expressed on activated CD4+ T-lymphocytes

Product Specifications

Recombinant Mouse CD40 ligand (Cd40lg), partial (Active) is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 112-260aa, with N-terminal mFc1-tagged tag, molecular weight 42.1 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 0.3149 to 1.023 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling

Subcellular Location

Secreted

Tissue Specificity

Specifically expressed on activated CD4+ T-lymphocytes

Subunit

Homotrimer (PubMed:8095800). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity)

Gene: Cd40lg  |  Organism: Mus musculus  |  Synonyms: T-cell antigen Gp39; TNF-related activation protein; Tumor necrosis factor ligand superfamily member 5

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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