Recombinant Mouse Corticoliberin (Crh)

Function

Hormone that plays a central role in whole body adaptation to stress (PubMed:16682628, PubMed:22992525, PubMed:23470617, PubMed:7830793). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2 (PubMed:22992525). CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:22992525). Also involved in social behavior by triggering a signaling in the prefrontal cortex that favor social interactions with novel conspecifics over familiar ones (PubMed:37669667). Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the timing of labor (By similarity). Also acts as a regulator of blastocyst implantation by promoting decidualization, regulating trophoblast invasion and facilitating maternal immune tolerance (By similarity)

Subcellular Location

Secreted

Tissue Specificity

Expressed in parvocellular paraventricular nucleus of the hypothalamus and in medial accessory olivary nucleus

• Seasholtz A.F. et al. Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene. — Mol. Cell. Neurosci. (1991)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Muglia L. et al. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. — Nature (1995)
• Donelan J. et al. Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process. — Proc. Natl. Acad. Sci. U.S.A. (2006)
• Lemos J.C. et al. Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. — Nature (2012)
• Sun Y. et al. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. — Gastroenterology (2013)
• Li K. et al. A cortical circuit for sexually dimorphic oxytocin-dependent anxiety behaviors. — Cell (2016)
• de Leon Reyes N.S. et al. Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice. — Cell (2023)