Function
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Biological Context
Subcellular Location: Secreted
Tissue Specificity: Expressed in activated CD8(+) T cells. In the thymus, expressed by medullary thymic epithelial cells
Product Specifications
Recombinant Mouse Lymphotactin protein (Xcl1) (Active) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 22-114aa, with Tag-Free tag, molecular weight 10.1 kDa, purity >97% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of >2.0x104 IU/mg.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.