Recombinant Mouse Receptor-type tyrosine-protein phosphatase S (Ptprs), partial, Mus musculus (Mouse), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 39.2kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Mouse Receptor-type tyrosine-protein phosphatase S (Ptprs), partial

Recombinant Mouse Receptor-type tyrosine-protein phosphatase S (Ptprs), partial — Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Purity >85%.

SKU: BCRECP-004208 Categories: ,
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Product Specifications

Product SkuBCRECP-004208
Product DescriptionRecombinant Mouse Receptor-type tyrosine-protein phosphatase S (Ptprs) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1631-1907aa. [Accession | B0V2N1].
Uniprot No.B0V2N1
Gene NamesPtprs
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1631-1907aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight39.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Cell projection, axon; Perikaryon; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Synapse, synaptosome; Postsynaptic density; Cell projection, neuron projection; Cell projection, growth cone
Tissue Specificity: Detected in brain cortex, cerebellum and thoracic spinal cord (at protein level). Detected in motor cortex and white matter of the spinal cord, but not in spinal cord gray matter. Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum and cerebellum) and to a lesser extent in the heart and skeletal muscle. Also found in neuronal-derived cell lines. Detected in the ganglion cell layer of the retina and in glial cells along the optic nerve. Detected in bone marrow and spleen plasmacytoid dendritic cells

Product Specifications

Recombinant Mouse Receptor-type tyrosine-protein phosphatase S (Ptprs), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1631-1907aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 39.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19780196, PubMed:19833921, PubMed:21454754, PubMed:22406547, PubMed:22519304). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as a tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Cell projection, axon; Perikaryon; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Synapse, synaptosome; Postsynaptic density; Cell projection, neuron projection; Cell projection, growth cone

Tissue Specificity

Detected in brain cortex, cerebellum and thoracic spinal cord (at protein level) (PubMed:19780196, PubMed:22519304). Detected in motor cortex and white matter of the spinal cord, but not in spinal cord gray matter (PubMed:19780196). Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum and cerebellum) and to a lesser extent in the heart and skeletal muscle. Also found in neuronal-derived cell lines (PubMed:7529177). Detected in the ganglion cell layer of the retina and in glial cells along the optic nerve (PubMed:15797710). Detected in bone marrow and spleen plasmacytoid dendritic cells (PubMed:26231120)

Subunit

Binding to large heparan sulfate proteoglycan structures promotes oligomerization (PubMed:21454754). Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (PubMed:21454754). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity)

Gene: Ptprs  |  Organism: Mus musculus  |  Synonyms: PTPNU-3; Receptor-type tyrosine-protein phosphatase sigma
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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