Recombinant Mouse Reticulon-3 (Rtn3), partial, Mus musculus (Mouse), Yeast, C-terminal 6xHis-tagged, 29.9kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Reticulon-3 (Rtn3), partial

Recombinant Mouse Reticulon-3 (Rtn3), partial — May be involved in membrane trafficking in the early secretory pathway. Purity >85%.

SKU: BCRECP-004304 Category:
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Product Specifications

Product SkuBCRECP-004304
Product DescriptionRecombinant Mouse Reticulon-3 (Rtn3) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 182-440aa. [Accession | Q9ES97].
Uniprot No.Q9ES97
Gene NamesRtn3
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region182-440aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 6xHis-tagged
Molecular weight29.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Multi-pass membrane protein); Golgi apparatus membrane (Multi-pass membrane protein)
Tissue Specificity: Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in spinal cord. Isoform 1 is present in brain, where it is expressed in the neurons of cerebral cortex, hippocampus, hypothalamus and cerebellum (at protein level)

Product Specifications

Recombinant Mouse Reticulon-3 (Rtn3), partial is a recombinant protein from Mus musculus (Mouse), expressed in Yeast, covering amino acids 182-440aa, with C-terminal 6xHis-tagged tag, molecular weight 29.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (PubMed:24262037). Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition (By similarity)

Subcellular Location

Endoplasmic reticulum membrane (Multi-pass membrane protein); Golgi apparatus membrane (Multi-pass membrane protein)

Tissue Specificity

Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in spinal cord. Isoform 1 is present in brain, where it is expressed in the neurons of cerebral cortex, hippocampus, hypothalamus and cerebellum (at protein level)

Subunit

Homodimer. Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD (By similarity). Interacts with ATL1 and ATL2 (PubMed:19665976). Isoform 3 interacts with TMEM33 (PubMed:25612671). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity). Interacts with RIGI (By similarity). Interacts with TRIM25 (By similarity)

Gene: Rtn3  |  Organism: Mus musculus
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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