Recombinant Rabies virus Glycoprotein (G), partial, Rabies virus (strain India) (RABV), E.coli, N-terminal 6xHis-SUMO-tagged, 65.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Rabies virus Glycoprotein (G), partial

Recombinant Rabies virus Glycoprotein (G), partial — Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. Purity >90%.

SKU: BCRECP-002805 Categories: ,
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Product Specifications

Product SkuBCRECP-002805
Product DescriptionRecombinant Rabies virus Glycoprotein (G) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 20-459aa. [Accession | A3RM22].
Uniprot No.A3RM22
Gene NamesG
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region20-459aa
SpeciesRabies virus (strain India) (RABV)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight65.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Biological Context

Subcellular Location: Virion membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Rabies virus Glycoprotein (G), partial is a recombinant protein from Rabies virus (strain India) (RABV), expressed in E.coli, covering amino acids 20-459aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 65.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1 (By similarity). In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity)

Subcellular Location

Virion membrane (Single-pass type I membrane protein)

Subunit

Homotrimer (By similarity). Interacts with matrix protein (By similarity). Interacts with host TRFC. Interacts with host BST2; this interaction inhibits viral budding by tethering new virions to the cell surface. Interacts with ITGB1. Interacts with host GRM2 (By similarity)

Gene: G  |  Organism: Rabies virus (strain India)

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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