Recombinant Human Nectin-4 (NECTIN4), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 36.9 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Nectin-4 (NECTIN4), partial (Active)

Recombinant Human Nectin-4 (NECTIN4), partial (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCACP-000152 Category:
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Product SKUBCACP-000152
Product DescriptionRecombinant Human Nectin-4 (NECTIN4) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 32-349aa. [Accession | Q96NY8].
Uniprot No.Q96NY8
Gene NamesNECTIN4
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region32-349aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight36.9 kDa
ActivityFACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Ig superfamily receptor LNIR)(Nectin cell adhesion molecule 4)(Poliovirus receptor-related protein 4)

Function

(Microbial infection) Acts as a receptor for measles virus.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma
Disease Association: Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) : A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Nectin-4 (NECTIN4), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 32-349aa, with C-terminal 10xHis-tagged tag, molecular weight 36.9 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Acts as a receptor for measles virus

Subcellular Location

Secreted

Disease Association

Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) : A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma

Subunit

(Microbial infection) Interacts (via N-terminus) with measles virus hemagglutinin protein (PubMed:22048310, PubMed:23202587)

Gene: NECTIN4  |  Organism: Homo sapiens  |  Synonyms: Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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