Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 7.6 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) — Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Purity >95%.

SKU: BCACP-000531 Categories: ,
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Product SKUBCACP-000531
Product DescriptionRecombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 1-54aa. [Accession | Q02223].
Uniprot No.Q02223
Gene NamesTNFRSF17
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region1-54aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight7.6 kDa
ActivityMeasured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 26.52-46.24 pg/mL.;Measured by its binding ability in a functional ELISA.Immobilized Mouse Tnf at 2 μg/mL can bind Human TNFRSF1A . The EC50 is 5.832-6.608 ng/mL.;Human TNFRSF1A captured on Protein A Chip can bind Recombinant Mouse Tnf with an affinity constant of 1.24 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesB-cell maturation protein (CD_antigen: CD269)(BCM) (BCMA)

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Biological Context

Subcellular Location: Cell membrane (Single-pass type III membrane protein); Endomembrane system (Single-pass type III membrane protein)
Tissue Specificity: Expressed in mature B-cells, but not in T-cells or monocytes
Disease Association: [A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2]

Product Specifications

Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 1-54aa, with C-terminal 10xHis-tagged tag, molecular weight 7.6 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK

Subcellular Location

Cell membrane (Single-pass type III membrane protein); Endomembrane system (Single-pass type III membrane protein)

Disease Association

[A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2]

Tissue Specificity

Expressed in mature B-cells, but not in T-cells or monocytes

Subunit

Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6

Gene: TNFRSF17  |  Organism: Homo sapiens  |  Synonyms: B-cell maturation protein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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