Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 47.9 kDa, purity >95% as determined by SEC-HPLC.
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Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active)

Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active) — Receptor for endothelin-1. Purity >95%.

SKU: BCACP-000169 Categories: ,
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Product SKUBCACP-000169
Product DescriptionRecombinant Human Endothelin-1 receptor (EDNRA)-VLPs protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 21-427aa. [Accession | P25101].
Uniprot No.P25101
Gene NamesEDNRA
PurityGreater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region21-427aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight47.9 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Macaca mulatta MAPT at 2 μg/mL can bind anti-MAPT recombinant antibody ,the EC50 is 2.464-3.979 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesEndothelin-1 receptor; Endothelin receptor type A; EDNRA; ETA, ETRA

Function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels
Disease Association: Mandibulofacial dysostosis with alopecia (MFDA) : A form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 21-427aa, with C-terminal 10xHis-tagged tag, molecular weight 47.9 kDa, purity Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca mulatta MAPT at 2 μg/mL can bind anti-MAPT recombinant antibody ,the EC50 is 2.464-3.979 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

Mandibulofacial dysostosis with alopecia (MFDA) : A form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels

Subunit

Interacts with HDAC7 and KAT5

Gene: EDNRA  |  Organism: Homo sapiens  |  Synonyms: Endothelin receptor type A
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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