Recombinant Human herpesvirus 8 type P Viral macrophage inflammatory protein 2 (VMI2), partial (Active), Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus), E.Coli, Tag-Free, 8.0 kDa, purity >>97% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 8 type P Viral macrophage inflammatory protein 2 (VMI2), partial (Active)

Recombinant Human herpesvirus 8 type P Viral macrophage inflammatory protein 2 (VMI2), partial (Active) — Viral CC chemokine that binds to a broad spectrum of viral and human chemokine receptors and, depending on the receptor, acts either as an antagonist or an agonist. Purity >97%.

SKU: BCACP-000881 Categories: ,
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Product SKUBCACP-000881
Product DescriptionRecombinant Kaposi's sarcoma-associated herpesvirus Viral macrophage inflammatory protein 2 (VMI2) protein is expressed from E.Coli with Tag-Free. It contains 24-93aa. [Accession | Q98157].
Uniprot No.Q98157
Gene NamesORF
Purity>97% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region24-93aa
SpeciesHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Tag InfoTag-Free
Molecular weight8.0 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by the apoptotic effect using serum free human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of >2.5x104 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesORF; K4; Viral macrophage inflammatory protein 2; Viral macrophage inflammatory protein II; vMIP-II; vMIP-1B

Function

Viral CC chemokine that binds to a broad spectrum of viral and human chemokine receptors and, depending on the receptor, acts either as an antagonist or an agonist. Capable of binding to chemokine receptors of the 4 families (CCR, CXCR, XCR, and CX3CR). Acts as an antagonist toward CCR1, CCR2, CCR5, and CCR10, competing with the endogenous chemokine binding and signaling.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Human herpesvirus 8 type P Viral macrophage inflammatory protein 2 (VMI2), partial (Active) is a recombinant protein from Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus), expressed in E.Coli, covering amino acids 24-93aa, with Tag-Free tag, molecular weight 8.0 kDa, purity >97% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the apoptotic effect using serum free human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of >2.5x104 IU/mg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Viral CC chemokine that binds to a broad spectrum of viral and human chemokine receptors and, depending on the receptor, acts either as an antagonist or an agonist. Capable of binding to chemokine receptors of the 4 families (CCR, CXCR, XCR, and CX3CR). Acts as an antagonist toward CCR1, CCR2, CCR5, and CCR10, competing with the endogenous chemokine binding and signaling (PubMed:9287217). On the other hand, acts as an agonist of CCR3 and CCR8, triggering G protein-mediated intracellular calcium release and activation of the ERK and PI3K/AKT signaling pathways, or chemotaxis (PubMed:9323208, PubMed:9834206, PubMed:11500830). Thereby, participates in the skewing of the host immune system away from the Th1 cytotoxic response, undesirable for the virus-infected cells, toward a Th2 response, which is less effective against intracellular pathogens (PubMed:9834206, PubMed:11500830). CXCR7 acts as a scavenger receptor for vCCL2, regulating its availability and activity toward other host receptors (PubMed:27238288)

Subcellular Location

Secreted

Subunit

Monomer. Interacts with human chemokine receptor CXCR4 (PubMed:25612609). Interacts with host CCR3 (PubMed:9323208, PubMed:11500830). Interacts with host CCR8 (PubMed:9834206). Interacts with host CCR1, CCR2 and CCR5 (PubMed:9287217). Interacts with ACKR3/CXCR7; this interaction regulates vCCL2 availability and activity toward human receptors (PubMed:27238288)

Gene: vCCL2  |  Organism: Human herpesvirus 8 type P (isolate GK18)  |  Synonyms: Viral macrophage inflammatory protein II; vMIP-1B
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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