Function
Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F.
Biological Context
Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed in astrocytes
Product Specifications
Recombinant Human Killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 22-340aa, with C-terminal 10xHis-tagged tag, molecular weight 36.4KDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GAS6 at 4 μg/mL can bind Human AXL . The EC50 is 1.100-1.324 ng/mL.;Human AXL captured on Protein A Chip can bind Recombinant Human GAS6 with an affinity constant of 3.65 nM as detected by MetaSPR Assay (WeSPRTM 200).;Measured by its binding ability in a functional ELISA. Immobilized Human GAS6 at 2 μg/mL can bind Anti-GAS6 recombinant antibody . The EC50 is 12.31-14.86 ng/mL.;GAS6 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human GAS6 with an affinity constant of 0.767 nM as detected by MetaSPR Assay (WeSPRTM 200).
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
