Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active), Homo sapiens (Human), Mammalian cell, N-terminal hFc-Flag-tagged, 42.8 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active)

Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active) — Cytokine that binds to TNFRSF18/AITR/GITR. Purity >90%.

SKU: BCACP-000095 Categories: ,
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Product SKUBCACP-000095
Product DescriptionRecombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18) protein is expressed from Mammalian cell with N-terminal hFc-Flag-tagged. It contains 72-199aa. [Accession | Q9UNG2].
Uniprot No.Q9UNG2
Gene NamesTNFSF18
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region72-199aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal hFc-Flag-tagged
Molecular weight42.8 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFRSF1B , the EC50 is 1.632-2.699 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1, the EC50 of human LTA protein is 4.409-6.797 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(AITRL)(hGITRL)(AITRL)(GITRL)(TL6)

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation.

Biological Context

Subcellular Location: Cell membrane (Single-pass type II membrane protein)
Tissue Specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells

Product Specifications

Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 72-199aa, with N-terminal hFc-Flag-tagged tag, molecular weight 42.8 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFRSF1B , the EC50 is 1.632-2.699 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1, the EC50 of human LTA protein is 4.409-6.797 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity)

Subcellular Location

Cell membrane (Single-pass type II membrane protein)

Tissue Specificity

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells

Subunit

Homodimer (By similarity). Homotrimer

Gene: TNFSF18  |  Organism: Homo sapiens  |  Synonyms: Activation-inducible TNF-related ligand; Glucocorticoid-induced TNF-related ligand
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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