Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active), Homo sapiens (Human), Mammalian cell, N-terminal hFc-Flag-tagged, 42.8 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active)

Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active) — Cytokine that binds to TNFRSF18/AITR/GITR. Purity >90%.

SKU: BCACP-000095 Categories: ,
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Product SKUBCACP-000095
Product DescriptionRecombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18) protein is expressed from Mammalian cell with N-terminal hFc-Flag-tagged. It contains 72-199aa. [Accession | Q9UNG2].
Uniprot No.Q9UNG2
Gene NamesTNFSF18
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region72-199aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal hFc-Flag-tagged
Molecular weight42.8 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFRSF1B , the EC50 is 1.632-2.699 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1, the EC50 of human LTA protein is 4.409-6.797 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(AITRL)(hGITRL)(AITRL)(GITRL)(TL6)

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation.

Biological Context

Subcellular Location: Cell membrane (Single-pass type II membrane protein)
Tissue Specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells

Product Specifications

Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 72-199aa, with N-terminal hFc-Flag-tagged tag, molecular weight 42.8 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity)

Subcellular Location

Cell membrane (Single-pass type II membrane protein)

Tissue Specificity

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells

Subunit

Homodimer (By similarity). Homotrimer

Gene: TNFSF18  |  Organism: Homo sapiens  |  Synonyms: Activation-inducible TNF-related ligand; Glucocorticoid-induced TNF-related ligand
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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