Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 6xHis-hFc-tagged, 48.7 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active) — Acts as a receptor for the cytotoxic ligand TRAIL but does not contain the intracellular death domain required to initiate apoptosis. Purity >95%.

SKU: BCACP-001250 Categories: ,
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Product SKUBCACP-001250
Product DescriptionRecombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) protein is expressed from Mammalian cell with C-terminal 6xHis-hFc-tagged. It contains 26-221aa. [Accession | O14798].
Uniprot No.O14798
Gene NamesTNFRSF10C
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region26-221aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-hFc-tagged
Molecular weight48.7 kDa
ActivityThe ED50 as determined in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D is 3.5 pg/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesTNFRSF10C; DCR1; LIT; TRAILR3; TRID; UNQ321/PRO366; Tumor necrosis factor receptor superfamily member 10C; Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD antigen CD263

Function

Acts as a receptor for the cytotoxic ligand TRAIL but does not contain the intracellular death domain required to initiate apoptosis. By competing with the functional TRAIL receptors TNFRSF10A and TNFRSF10B for ligand binding, it functions as a decoy receptor that protects cells from TRAIL-induced apoptosis.

Product Specifications

Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 26-221aa, with C-terminal 6xHis-hFc-tagged tag, molecular weight 48.7 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Acts as a receptor for the cytotoxic ligand TRAIL but does not contain the intracellular death domain required to initiate apoptosis. By competing with the functional TRAIL receptors TNFRSF10A and TNFRSF10B for ligand binding, it functions as a decoy receptor that protects cells from TRAIL-induced apoptosis

Gene: TNFRSF10C  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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